Tissue distribution and urinary excretion of intravenously administered chemically functionalized graphene oxide sheets.
نویسندگان
چکیده
The design of graphene-based materials for biomedical purposes is of great interest. Graphene oxide (GO) sheets represent the most widespread type of graphene materials in biological investigations. In this work, thin GO sheets were synthesized and further chemically functionalized with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), a stable radiometal chelating agent, by an epoxide opening reaction. We report the tissue distribution of the functionalized GO sheets labeled with radioactive indium (111In) after intravenous administration in mice. Whole body single photon emission computed tomography (SPECT/CT) imaging, gamma counting studies, Raman microscopy and histological investigations indicated extensive urinary excretion and predominantly spleen accumulation. Intact GO sheets were detected in the urine of injected mice by Raman spectroscopy, high resolution transmission electron microscopy (HR-TEM) and electron diffraction. These results offer a previously unavailable pharmacological understanding on how chemically functionalized GO sheets transport in the blood stream and interact with physiological barriers that will determine their body excretion and tissue accumulation.
منابع مشابه
Tissue distribution and urinary excretion of intravenously administered chemically functionalized graphene oxide sheets† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00114e Click here for additional data file.
متن کامل
بررسی جذب سطحی در نانوکامپوزیتهای گرافن/ اکسیدگرافن- پلیمرهای تقویت شده بهروش شبیهسازی دینامیک مولکولی واکنشی
Abstract: In this work, the amounts of the adsorption of conjugated polymers onto graphene/ graphene oxide were examined by reactive force-field molecular dynamics simulation. The polymers were poly(3-hexylthiophene) (P3HT) and poly(phenothiazine vinylene-polythiophene)(PTZV-PT). The length and width of the graphene sheet were 95.19 Å and 54.16 Å, respectively. The graphene oxide sheets with di...
متن کاملStudying the Corrosion Protection Behavior of an Epoxy Composite Coating Reinforced with Functionalized Graphene Oxide by Second and Fourth Generations of Poly(amidoamine) Dendrimers (GO-PAMAM-2, 4)
In this research, graphene oxide (GO) nanoparticles were modified by second and fourth generations of poly(amidoamine) dendrimers in order to improve the particle dispersion quality in the epoxy matrix and therefore its barrier anti-corrosion performance. Confirmation on the GO surface modification by Polyamidoamine generation 2 (PAMAM2) and polyamidoamin generation 4 (PAMAM4) was carried o...
متن کاملHigh Pt Loading on Polydopamine Functionalized Graphene as a High Performance Cathode Electrocatalyst for Proton Exchange Membrane Fuel Cells
Morphology and size of platinum nanoparticles are a crucial factor in improving their catalytic activity and stability. Here, we firstly report the synthesis of high loading Pt nanoparticles on polydopamine reduced Graphene. The loading concentration of Pt (nanoparticles) NPs on Graphene can be adjusted in the range of 60-70%.With the insertion of polydopamine between Graphene oxide sheets, sta...
متن کاملCovalent functionalization of polydisperse chemically-converted graphene sheets with amine-terminated ionic liquid.
A facile method to obtain polydisperse chemically-converted graphene sheets that are covalently functionalized with ionic liquid was reported -- the resulting graphene sheets, without any assistance from polymeric or surfactant stabilizers, can be stably dispersed in water, DMF, and DMSO.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical science
دوره 6 7 شماره
صفحات -
تاریخ انتشار 2015